Cell-type-specific computational neuroanatomy, simulations from the sagittal and coronal Allen Brain Atlas
نویسنده
چکیده
The Allen Atlas of the adult mouse brain is a brain-wide, genome-wide data set that has been made available online, triggering a renaissance in neuroanatomy. In particular, it has been used to define brain regions in a computational, data-driven way, and to estimate the region-specificity of cell types characterized independently by their transcriptional activity. However, these results were based on one series of co-registered (coronal) ISH image series per gene, whereas the online ABA contains several image series per genes, including sagittal ones. Since the sagittal series cover mostly the left hemisphere, we can simulate the variability of results by repeatedly drawing a random image series for each gene and restricting the computation to the left hemisphere. This gives rise to an estimate of error bars on the results of computational neuroanatomy. This manuscript is a complement to the paper Computational neuroanatomy: mapping cell-type densities in the mouse brain, simulations from the Allen Brain Atlas prepared for the International Conference on Mathematical Modeling in Physical Sciences June 5-8, 2015, Mykonos Island, Greece. 1 ar X iv :1 50 5. 06 43 4v 1 [ qbi o. N C ] 2 4 M ay 2 01 5 Acronyms. ABA: Allen Brain Atlas; ARA: Allen Reference Atlas; ISH: in situ hybridization.
منابع مشابه
Computational neuroanatomy: mapping cell-type densities in the mouse brain, simulations from the Allen Brain Atlas
The Allen Brain Atlas (ABA) of the adult mouse consists of digitized expression profiles of thousands of genes in the mouse brain, co-registered to a common three-dimensional template (the Allen Reference Atlas). This brain-wide, genome-wide data set has triggered a renaissance in neuroanatomy. Its voxelized version (with cubic voxels of side 200 microns) can be analyzed on a desktop computer u...
متن کاملCell-type-specific neuroanatomy of cliques of autism-related genes in the mouse brain
Two cliques of genes identified computationally for their high co-expression in the mouse brain according to the Allen Brain Atlas, and for their enrichment in genes related to autism spectrum disorder (ASD), have recently been shown to be highly co-expressed in the cerebellar cortex, compared to what could be expected by chance. Moreover, the expression of these cliques of genes is not homogen...
متن کاملCo-expression Profiling of Autism Genes in the Mouse Brain
Autism spectrum disorder (ASD) is one of the most prevalent and highly heritable neurodevelopmental disorders in humans. There is significant evidence that the onset and severity of ASD is governed in part by complex genetic mechanisms affecting the normal development of the brain. To date, a number of genes have been associated with ASD. However, the temporal and spatial co-expression of these...
متن کاملCell-type-specific neuroanatomy of brain-wide expression of autism-related genes
Two cliques of genes identified computationally for their high co-expression in the mouse brain according to the Allen Brain Atlas, and for their enrichment in genes related to autism spectrum disorder, have recently been shown to be highly co-expressed in the cerebellar cortex, compared to what could be expected by chance. Moreover, the expression of these cliques of genes is not homogeneous a...
متن کاملHigh resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl/6J mice
Detailed anatomical atlases can provide considerable interpretive power in studies of both human and rodent neuroanatomy. Here we describe a three-dimensional atlas of the mouse brain, manually segmented into 62 structures, based on an average of 32 mum isotropic resolution T(2)-weighted, within skull images of forty 12 week old C57Bl/6J mice, scanned on a 7 T scanner. Individual scans were nor...
متن کامل